Phenolic chelating agents as antidotes for acute uranyl acetate intoxication in mice

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Abstract
Phenolic chelating agents (9) were examined as antidotes for acute uranyl acetate intoxication. The ability of these compounds to promote survival was determined and the ability of 2 of them to remove U from the liver and kidney was compared with that of Na3 CaDTPA [diethylenetriaminepentaacetic acid]. The most effective compounds of this type in promoting survival were Tiron and p-aminosalicylic acid, but Tiron was much more effective in decreasing the U burden of the liver and kidneys. These compounds exhibit an antidotal at higher U levels than the compounds reported in earlier studies. The compounds all seem to possess a very modest toxicity when administered i.p.