THE PLASMA INSULIN-I^131 IN DIABETIC PATIENTS

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Abstract
The disappearance curve for I131 labeled insulin was studied in 20 diabetics and 6 normal individuals. This curve consisted of an initial rapid phase completed in a few minutes, and a slower second phase following a logarithmic relationship. The two parameters of the disappearance during the slow phase were studied, using the extrapolated value for the concentration at time zero as a measure of the distribution of the labeled material and using the slope of the curve as a measure of the rate of disappearance. Neither value alone was characteristic of any of the clinical groups studied with the exception of the value for the initial concentration of the insulin in the group of obese diabetics where the mean was significantly lower than that in the normal group.