Prevention and Treatment of Agranulocytosis and Leukopenia in Rats Given Sulfanilylguanidine or Succinyl Sulfathiazole in Purified Diets

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Abstract
Rats given sulfaguanidine (sulfanilylguanidine) or sulfasuxidine (succinyl sulfathiazole) in purified diets develop an agranulocytosis, a leukopenia, and a hypocellularity of bone marrow. This blood dyscrasia can largely be prevented or successfully treated with whole dried liver or with certain liver extracts.