Inotropic Action of Acetyl-Strophanthidin, Strophanthidin, and Tryptamine-Strophanthidin.

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Abstract
Papillary muscles from the right ventricle of the cat heart were stimulated in phosphate-buffered Krebs-Ringer soln. until their force of contraction declined. On addition of acetylstrophanthidin, tryptamine-strophanthidin, or strophanthidin to the papillary muscles, their force of contraction improved, and the improvement persisted throughout the period of observation (avg. 4.3 hrs.). It is concluded that these strophanthidin derivatives have a typical digitalis action on failing mammalian heart muscle.