Propagation of Infectious Canine Hepatitis Virus in Tissue Culture

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Abstract
The serial propagation of ICH virus by the roller tube method in dog kidney tissue culture through 15 consecutive passages is reported. The growth of the virus under these conditions causes a specific cytopathogenic degeneration of the tissue growth, similar to that reported for poliomyelitis virus in the presence of human or monkey tissues. Identification of the tissue culture virus was made by both the complement-fixation and serum neutralization methods using a known infectious canine hepatitis fox immune serum.