Studies of 7.BETA.-(2-(aminoaryl)acetamido)-cephalosporin derivatives. III. Synthesis and structure-activity relationships in the aminothiadiazole series.
- 1 January 1984
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 37 (5) , 557-571
- https://doi.org/10.7164/antibiotics.37.557
Abstract
The synthesis and in vitro antibacterial activity of 7.beta.-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-oxyiminoacetamido]cephalosporins with various substituents at the 3-position in the cephem nucleus are described. Aminothiadiazolyl cephalosporins having pyridiniomethyl groups at the 3-position exhibited excellent activity against all organisms, particularly against Pseudomonas aeruginosa.This publication has 3 references indexed in Scilit:
- Studies of 7.BETA.-(2-(aminoaryl)acetamido)-cephalosporin derivatives. II. Synthesis and structure-activity relationships in the aminopyrimidine series.The Journal of Antibiotics, 1984
- Studies of 7.BETA.-(2-(aminoaryl)acetamido)-cephalosporin derivatives. I. Synthesis and structure-activity relationships in the aminopyridine series.The Journal of Antibiotics, 1984
- Cephalosporin antibiotics. Synthesis and antimicrobial activity of 7.BETA.-(2-(5-amino-1,2,4-thiadiazol-3-yl)-2-oxyiminoacetamido)cephalosporin derivatives.The Journal of Antibiotics, 1983