THE EFFECT OF DIETHYLSTILBESTROL UPON ALLOXAN DIABETES IN THE MALE RAT

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Abstract
The effect of diethylstilbestrol upon alloxan diabetes was studied in rats which were force-fed and in similar animals which ate ad libitum. Diethylstilbestrol was found to cause exacerbation of diabetes in the force-fed rat, but in similar animals eating ad libitum, the diabetogenic effect of the estrogen was either partly or completely masked by the concomitant decrease in food intake. In animals having severe alloxan diabetes, the admn. of diethylstilbestrol caused a sharp decrease in glyco-suria due to a decrease in the voluntary intake of food.