Quantitative correlation between carcinogenicity and sister chromatid exchange inductionin vivofor a group of 11n‐nitroso derivatives
- 1 March 1983
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 11 (3) , 337-346
- https://doi.org/10.1080/15287398309530347
Abstract
The quantitative correlation between induction of sister chromatid exchanges (SCE) in vivo and carcinogenic potency was examined for 11 nitroso derivatives [dimethylnitrosamine, diethylnitrosamine, di-n-butyl-nitrosamine, di-n-propylnitrosamine, methylnitrosourea, N-nitrosomorpholine, N-nitrosopiperidine, streptozotocin, ethylnitrosourea, N-methyl-N''-nitro-N-nitrosoguanidine N-nitrosopyrrolidine], and was compared with the correlation of alkaline DNA fragmentation in liver DNA in vivo and with the Ames test. The correlation between DNA adducts and SCE was also evaluated. DNA damage was slightly more predictive and the Ames test less predictive than SCE evaluation. The predictivity of these tests for this class of compounds was compared with the predictivity shown for different classes of chemical compounds.This publication has 21 references indexed in Scilit:
- Quantitative correlations amongst alkaline DNA fragmentation, DNA covalent binding, mutagenicity in the Ames test and carcinogenicity, for 21 compoundsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1982
- Study of 106 organic and inorganic compounds in the Salmonella/microsome testCarcinogenesis: Integrative Cancer Research, 1981
- Quantitative correlation among DNA damaging potency of six N-nitroso compounds and their potency in inducing tumor growth and bacterial mutationsCarcinogenesis: Integrative Cancer Research, 1981
- Detection by alkaline elution of rat liver DNA damage induced by simultaneous subacute administration of nitrite and aminopyrineJournal of Toxicology and Environmental Health, 1980
- In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesisMutation Research/Reviews in Genetic Toxicology, 1979
- DNA damage induced in vivo evaluated with a non-radioactive alkaline elution techniqueCancer Letters, 1979
- The relationship between mutagenicity and carcinogenicity of some nitrosaminesMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1978
- A comparison of the HeLa DNA-synthesis inhibition test and the Ames test for screening of mutagenic carcinogensMutation Research/Environmental Mutagenesis and Related Subjects, 1978
- A simplified technique for in vivo analysis of sister-chromatid exchanges using 5-bromodeoxyuridine tabletsCytogenetic and Genome Research, 1977
- Cytological detection of mutagen–carcinogen exposure by sister chromatid exchangeNature, 1975