Cytopathogenicity in Tissue Cultures by a Tumor Virus from Mice

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Abstract
Hamsters, 1 to 3 days old, injected with fluid from SE polyoma virus-infected cultures showing cytopathogenic changes developed tumors within 26 days whereas only 3 of 9 hamsters injected with fluid from normal appearing cultures developed tumors after 43 days. Further correlation of cytopathogenicity and tumor induction was demonstrated by a reduction in the cytopathogenic titer of the virus when virus dilutions were combined with 1% specific immune rabbit serum and by the degenerative changes in cell cultures and the induction of tumors in hamsters by a virus preparation filtered through a gradocol membrane of 120 mu porosity and failure of a filtrate of the same virus preparation filtered through a membrane of 77 m[mu] pore size to cause either cytopathogenic changes in cell cultures or the development of tumors in hamsters.