THE INFLUENCE OF BLOOD GLUCOSE ON THE RENAL CLEARANCE OF PHOSPHATE12

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Abstract
Studies on the influence of blood sugar and inorganic phosphate levels on inorganic phosphate excretion by the kidney in 40 normal men are presented. The data indicate that the concentrations of glucose and phosphate in the blood exert powerful, sensitive and inde-pendent influences on phosphate excretion by the kidney. At hyperglycemic levels, the influence of blood glucose predominates over that of plasma phosphate, whereas at hypoglycemic levels the influence of plasma phosphate takes precedence. This mechanism may play an important physiologic role in the minute to minute regulation of renal phosphate excretion in man and that other factors (such as insulin) may exert their influence via alteration of blood glucose or phosphate levels.