Studies in detoxication. 62. The metabolism of halogenobenzenes. Ortho- and para-dichlorobenzenes

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Abstract
O-Dichlorobenzene, when fed to rabbits (0.5 g/kg), is mainly oxidized to 3:4-dichlorophenol, which is excreted conjugated with glucuronic and sulfuric acids. Conjugates of 2:3-dichlorophenol, 4:5-dichlorocatechol and 3:4-dichloro-catechol are also excreted as minor metabolites. o-Dichloro-benzene also gives rise to 3:4-dichlorophenylmercapturic acid as a minor metabolite (5% of the dose). p-Dichlorobenzene (0.5 g/kg) is mainly oxidized to 2:5-dichlorophenol which is excreted conjugated. 2:5-Dichloroquinol is also formed (about 6% of the dose) but in contrast with o-dichlorobenzene no mercapturic acid or dichlorocatechol is formed. The excretion of the metabolites of o-dichlorobenzene is slow and appears to be complete in 5-6 days after dosing. With the para isomer, the excretion of metabolites is not complete and is still appreciable after 6 days.

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