URINARY PABA RECOVERY AFTER ORAL N-BENZOYL-L-TYROSYL-PABA ADMINISTRATION COMBINED WITH VARIOUS EXOCRINE PANCREATIC STIMULANTS
- 1 January 1980
- journal article
- research article
- Vol. 27 (3) , 224-226
Abstract
Eleven healthy volunteers (C) and 9 patients affected by chronic relapsing pancreatitis (CP) were administered N-benozyl-L-tyrosyl-PABA [p-aminobenzoic acid] orally, at a dose of 150 mg combined, on different days, with water alone (schedule a); Lundh meal (schedule b); secretin-caerulein by i.v. infusion (0.5 CU[convalescent uni]/kg per h and 75 ng/kg per h, respectively) (schedule c); and, caerulein by i.m. injection (300 ng/kg) (schedule d). The mean urinary PABA recovery in CP was lower than in C with all the schedules, but this was statistically significant only with schedules a and c (P < 0.02 and < 0.05, respectively). With respect to b, c and d, the mean urinary PABA recovery seemed to increase both in C and in CP as compared with schedule a, but only in the CP group with schedule b was the increase statistically significant (P < 0.05). The exocrine pancreatic stimulants do not improve the reliability of the PABA test for exocrine pancreatic insufficiency.This publication has 3 references indexed in Scilit:
- EXOCRINE PANCREATIC FUNCTION-TEST BY A SYNTHETIC PEPTIDE1979
- INDIRECT ASSESSMENT OF EXOCRINE PANCREATIC FUNCTION BY ORAL-ADMINISTRATION OF A SYNTHETIC PEPTIDE, N-BENZOYL-L-TYROSYL-PARA-AMINO-BENZOIC-ACID (PABA TEST)1979
- ORAL-ADMINISTRATION OF CHYMOTRYPSIN LABILE PEPTIDE FOR A NEW TEST OF EXOCRINE PANCREATIC FUNCTION (PFT) IN COMPARISON WITH PANCREOZYMIN-SECRETIN TEST1978