Chromosome 8 breakpoint far 3′ of the c-myc oncogene in a Burkitt's lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus.

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Abstract
The 2;8 variant translocation of human Burkitt's lymphomas is closely related cytogenetically to the t(6;15) of murine plasmacytomas; both involve a reciprocal exchange between the Ig kappa locus and a band region indistinguishable from that bearing the c‐myc oncogene. To define their molecular relationship, we have compared cloned chromosome 8 DNA from the t(2;8) breakpoint in the human Burkitt's lymphoma JBL2 with cloned DNA from the murine pvt‐1 locus, the major chromosome 15 breakpoint region in murine t(6;15). DNA sequencing and Southern blot analysis shows that these two regions are homologous. Thus the t(2;8) in JBL2 is the molecular equivalent of many murine t(6;15). The murine pvt‐1 locus lies an unknown distance 3′ of c‐myc; analysis of DNA from several tumours with c‐myc amplification reveals that pvt‐1 is co‐amplified in at least one case, placing pvt‐1 approximately 100‐500 kb 3′ of c‐myc. The significance of these results with respect to the role of pvt‐1 in tumorigenesis is discussed.

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