The influence of sucralfate on ibuprofen absorption in healthy adult males

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Abstract
Sucralfate (Carafate®) is a new anti‐ulcer agent the effects of which are mediated locally in the gastrointestinal tract. The use of this compound in conjunction with ulcerogenic drugs such as ibuprofen may represent a means of reducing gastrointestinal irritation. Combined oral therapy, however, requires evaluation of a potential interaction in absorption between those agents. The purpose of this study was to examine the influence of sucralfate coingestion on ibuprofen absorption. Twelve normal, healthy male subjects ingested a single oral 400 mg dose of ibuprofen alone or with sucralfate given as 1 g doses four times a day for 2 days prior to and during the study. Ibuprofen serum concentrations were measured for 12 hours following dosing. Parameters associated with rate of absorption (i.e. Cmax, tmax, Ka) were significantly altered in the presence of sucralfate (p < 0.05). In contrast, the relative bioavailability of ibuprofen was not significantly different between treatments (p > 0.05). Therefore, sucralfate does not alter the extent of ibuprofen absorption and would not be expected to change the response to that anti‐inflammatory agent.

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