THE SIZE OF THE EXTRACELLULAR FLUID COMPARTMENT BEFORE AND AFTER MASSIVE INFUSIONS

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Abstract
The distr. of Cl and of injected NaSCN was used to detn. the total extracellular water of cats and the fraction of this extracellular water contained in the component organs. Analyses of the organs show these substances are not limited to the extracellular compartment in the case of the stomach, small and large intestine, spleen, pancreas and skin. The last named organ contains these substances in amts. to give a water content equal to the total water, on the assumption that these substances are contained in the tissue water in approx. the same conc. as their conc. in the blood plasma. Massive infusions of 1% NaCl soln. are limited, for the most part, to the extracellular compartment in the period of time during and immediately following infusion. Massive infusions of glucose soln. are likewise limited to the extracellular compartment. In some instances, the cells show an increased permeability to NaSCN following infusion with glucose soln.

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