Der Verteilungsraum von physikalisch gelöstem Sauerstoff in wäßrigen Lösungen organischer Substanzen / The Distribution Space of Physically Dissolved Oxygen in Aqueous Solutions of Organic Substances

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Abstract
To evaluate the distribution of O2 in biological systems, the O2 solubility (ml/ml atm) at 37.degree. C in aqueous solutions of 30 organic substances [sugars, carbohydrates, ATP, ADP, urea, acetylcholine, choline chloride, amino acids, proteins] with different concentrations was measured by the classical Van Slyke principle. The O2 solubility (with the exception of Hb) decreases exponentially with increasing concentration of the respective substance. In all cases this behavior is described as highly significant by a simple empiric exponential function, when the substance concentration and the O2 solubility of pure water is given. The influence of one substance on O2 solubility contributes additively to the over-all solubility value of a solution of several dissolved substances. Changes in O2 solubility and O2 distribution in aqueous solutions may be related to 3 main phenomena: restriction of the free water volume by the specific partial volume of a dissolved substance (e.g., urea solutions), existence of non-solvent water for O2 (especially in solutions of amino acids) and adsorption of O2 at the interphase in a heterogenous system (e.g., protein solutions).

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