NORADRENALINE SENSITIVITY IN HYPERTENSION MEASURED WITH A RADIOACTIVE SODIUM TECHNIQUE
Open Access
- 1 April 1958
- Vol. 20 (2) , 224-228
- https://doi.org/10.1136/hrt.20.2.224
Abstract
Radioactive Na24 was injected into the quadriceps muscle and the needle left in situ; 0.2 ml of norepinephrine was then injected through the same needle in 10 patients with normal pressure and in 20 hypertensive subjects. The mean clearance rates of Na24 in these groups did not differ significantly before norepinephrine nor was there any difference in the mean clearances of both groups after norepinephrine injection. However, the mean change in time to half value after the injection of norepinephrine was significantly greater in the hypertensive subjects. This indicates that the blood vessels of hypertensive patients have an increased sensitivity to intramuscular norepinephrine.Keywords
This publication has 11 references indexed in Scilit:
- ADRENALINE SENSITIVITY OF PERIPHERAL BLOOD VESSELS IN HUMAN HYPERTENSIONHeart, 1957
- THE RELATIONSHIP BETWEEN BLOOD FLOW, CAPILLARY SURFACE AREA AND SODIUM CLEARANCE IN MUSCLE1955
- THE REACTIVITY OF THE CAPILLARY BED OF THE NAILFOLD TO CIRCULATING EPINEPHRINE AND NOR-EPINEPHRINE IN PATIENTS WITH NORMAL BLOOD PRESSURE AND WITH ESSENTIAL HYPERTENSIONJournal of Clinical Investigation, 1952
- Consistency of clearance of radioactive sodium from human muscleAmerican Heart Journal, 1951
- PERIPHERAL VASCULAR HEMODYNAMICS IN THE BULBAR CONJUNCTIVA OF SUBJECTS WITH HYPERTENSIVE VASCULAR DISEASE 123Journal of Clinical Investigation, 1951
- CALF MUSCLE BLOOD FLOW, BEFORE AND AFTER OPERATION AND DURING VARIOUS NORMAL AND PATHOLOGIC STATES1951
- THE COMPARATIVE EFFECTS OF SMALL INTRAVENOUS DOSES OF L-NOR-EPINEPHRINE UPON ARTERIAL PRESSURE AND PULSE RATE IN NOR-MOTENSIVE SUBJECTS AND IN HYPERTENSIVE PATIENTS BEFORE AND AFTER THORACOLUMBAR SYMPATHECTOMYJournal of Clinical Investigation, 1950
- Measurement of regional circulation by the local clearance of radioactive sodiumAmerican Heart Journal, 1949
- The hemodynamic response of man to nor-epinephrine and epinephrine and its relation to the problem of hypertensionThe American Journal of Medicine, 1948
- PROCEEDINGS OF THE PHYSIOLOGICAL SOCIETY OF PHILADELPHIAThe Lancet Healthy Longevity, 1948