Interaction of Methandrostenolone and Adrenocortical Hormones

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Abstract
This study concerns the interaction between the anabolic steroid methandrostenolone (17[alpha]- methyl-17[beta]-hy-droxyandrosta-1,4-dien-3-one; DianabolR) and adrenocortical hormones in rats. The administration of methandrostenolone to intact or castrate male rats partially antagonized the growth inhibiting effects of gluco-corticoid administration. Studies on experimental inflammation were performed using methandrostenolone alone and in combination with glucocorticoids. The systemic injection of methandrostenolone alone to intact rats with granuloma pouches did not appreciably affect the volume of exudate formed in the pouches; however, when given together with the glucocorticoids, it did result in a significant decrease in the volume of exudate as compared to that obtained with the glucocorticoids alone. The administration of the anabolic steroid to intact or adrenalectomized rats with sterile cotton pellet implants resulted in a slight decrease in the weight of the granuloma. With this procedure there was an additive effect when methandrostenolone and the glucocorticoids were given in combination. Similar augmentation of glucocorticoid activity was found with methyl testosterone and testosterone, whereas nore-thandrolone and progesterone were inactive. Methandrostenolone itself showed no other signs of glucocorticoid-like activity.

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