The 3′ region of bovine leukemia virus genome encodes a trans-activator protein.
Open Access
- 1 October 1986
- journal article
- research article
- Published by Wiley in The EMBO Journal
- Vol. 5 (10) , 2585-2589
- https://doi.org/10.1002/j.1460-2075.1986.tb04538.x
Abstract
The genome of bovine leukemia virus (BLV) contains several overlapping, long open reading frames 3′ to the envelope gene. Experiments presented here show that the cDNA encompassing the X region open reading frames encodes a trans‐activator function capable of increasing the level of gene expression directed by the BLV long terminal repeat sequences. This study provides further evidence of the structural and functional similarities of the bovine leukemia virus and the human T lymphotropic viruses, HTLV‐I and HTLV‐II.This publication has 27 references indexed in Scilit:
- Trans -Activator Gene of HTLV-II Induces IL-2 Receptor and IL-2 Cellular Gene ExpressionScience, 1986
- Location of the Trans -Activating Region on the Genome of Human T-Cell Lymphotropic Virus Type IIIScience, 1985
- HTLV x -Gene Product: Requirement for the env Methionine Initiation CodonScience, 1985
- A Transcriptional Activator Protein Encoded by the x- lor Region of the Human T-Cell Leukemia VirusScience, 1985
- Studies of the Putative Transforming Protein of the Type I Human T-Cell Leukemia VirusScience, 1985
- Trans -Acting Transcriptional Activation of the Long Terminal Repeat of Human T Lymphotropic Viruses in Infected CellsScience, 1984
- Nonspecific integration of the HTLV provirus genome into adult T-cell leukaemia cellsNature, 1984
- Complete amino acid sequence of human T‐cell leukemia virus structural protein p15FEBS Letters, 1983
- Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphomaProceedings of the National Academy of Sciences, 1980
- Synthesis of rabbit β-globin in cultured monkey kidney cells following infection with a SV40 β-globin recombinant genomeNature, 1979