CRANIOPHARYNGIOMA WITH PANHYPOPITUITARISM: CASE REPORT WITH CLINICAL AND PATHOLOGICAL STUDY*

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Abstract
LONG-TERM clinical observations of glandular deficiencies in the human being afford one of the best means of determining the effects of each of the glands involved. In the present instance, the clinical course of a man with craniopharyngioma and hypopituitarism was followed for five years, during periods without treatment as well as at times when the effects of various glandular preparations were recorded. The unusual nature of some of these results, especially in regard to water and electrolyte1 balance, and the opportunity to study the postmortem data, have prompted this report. CASE REPORT P.B., an Italian by birth, died January 21, 1946, at the age of 55 years, following repeated admissions to the Metropolitan and other New York City hospitals for apparently minor but distressing low-grade infections associated with progressive weakness, and ease of fatigue on the slightest exertion. He had not been well since the age of 14 years, when he developed polyuria, polydipsia, and generalized constant headaches with a sense of pressure.

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