RESPONSE TO THYROTROPHIN‐RELEASING HORMONE AND TRIIODOTHYRONINE SUPPRESSIBILITY IN EUTHYROID MULTINODULAR GOITRE

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Abstract
In 22 female patients with euthyroid multinodular goiter of varying size, thyroid suppression of 131I thyroid uptake by triiodothyronine (T3) and thyrotropin (TSH) release after thyrotropin-releasing hormone (TRH) administration were compared with thyroid weight, estimated by a planimetric method, and with serum thyroxine (T4) and T3 concentrations. Maximal increment of TSH (.DELTA.TSH) after TRH and percent T3-suppressibility were inversely related to thyroid weight and not related to basal serum T4 or T3 concentrations. .DELTA.TSH and percent suppression correlated positively, but .DELTA.TSH was more often subnormal than T3-suppressibility. A practical consequence of the study is that nonconformity of the 2 tests may occur. This should be kept in mind in the evaluation of patients with thyroid disorders.