Synthesis of 6-(S) Deuterium-Labelled Derivatives of Maltose and Isomaltose.

Abstract
The 6-(S) deuterium-labelled compounds methyl .beta.-isomaltoside (4a), methyl .beta.-maltoside (8a) and methyl 4,6-di-O-(.alpha.-D-glucopyranosyl)-.beta.-D-glucopyranoside (12) have been synthesized from deuterium-substituted 1,6-anhydro compounds. The 6-(R) deuterium-labelled compound methyl .beta.-matoside (10) has been prepared by inversion at the 6-position of the corresponding 6-(S) derivative. The compounds have all been examined by 1H NMR spectroscopy at 500 MHz and their preferred solution conformation has been inferrred from the J56R and J56S coupling constants.