Peptide-Labeled Near-Infrared Quantum Dots for Imaging Tumor Vasculature in Living Subjects
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- 11 March 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 6 (4) , 669-676
- https://doi.org/10.1021/nl052405t
Abstract
We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.Keywords
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