Abstract
Drugs and drug combinations currently in use for chemical restraint of the horse are disussed to establish their usefulness to the practicing veterinary surgeon. Acepromazine maleate and xylazine hydrochloride are useful tranquilizers despite their limitations. A xylazine-methadone sequence is described for more profound chemical restraint and the possible future role of ketamine and glyceryl guaiacolate in combination with other agents to produce recumbency is discussed.