Comparative Study of Selected Coupling Reagents in Dipeptide Synthesis
- 1 February 1993
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 23 (3) , 349-356
- https://doi.org/10.1080/00397919308009787
Abstract
A comparative study of the effectiveness of selected coupling reagents in dipeptide synthesis was conducted. Included in the study were a new coupling reagent, pentafluorophenyl diphenylphosphinate (FDPP, 1), benzotriazol-1-yl-oxytris(dimethylamino) phosphonium hexafluorophosphate (BOP, 2), 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU, 3), and isobutyl chloroformate (IBCF, 4). We found that BOP (2) afforded the highest yields and lowest limits of racemization.Keywords
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