The Identification of Antibiotics by Means of Resistant Strains of Bacteria

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Abstract
A plan is proposed offering a systematic approach to the problem of early identification of unknown antibiotics and of prompt recognition of new types of antibiotics by means of resistant strains of bacteria filed with and obtainable from a public culture collection. The test for the identity of an unknown antibiotic with a known antibiotic is made by determining the "inhibition ratio" of the unknown under standard conditions. The ratio for the known antibiotic must be known beforehand. It is the relative concn. required to inhibit the resistant and parent strains. The known antibiotics are not themselves required for performing the tests. A model illustrating application of resistant strains to the problem of identification is given, together with a number of examples illustrating the utility of the method.
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