THE EFFECT OF HEMORRHAGE ON THE PLASMA AMINO NITROGEN OF THE DOG

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Abstract
After hemorrhage (produced without anesthesia by bleeding out and replacement of a percentage of the bleeding vol.) the arterial concn. of amino N rose. The rate of increase was an excellent criterion of the condition of the animal and correlated well with survival time. The femoral arterio-venous amino N difference increased and then decreased, remaining above control value. Although the arterio-portal difference increased reduced blood flow renders it unlikely that the viscera are a contributory factor toward the plasma amino N rise. The portal-hepatic difference increased continuously, but, since the arterial level rose markedly during the final hr., reduction in blood flow through the liver during this time may be inferred. The source of the additional amino N appears to be the muscles of the legs.

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