High-Pressure Liquid Chromatographic Analysis for Quantitation of BMY-28142 and Ceftazidime in Human and Rabbit Serum
- 1 June 1986
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 9 (8) , 1803-1814
- https://doi.org/10.1080/01483918608076719
Abstract
The quantitative measurement of BMY-28142 and ceftazidime in serum after protein precipitation were compared using a reverse-phase liquid chromatographic (LC) method. Detection using ultraviolet absorbance at 275 nm gave a sensitivity of 1.0 mcg/ml and 1.5 mcg/ml for BMY-28142 and ceftazidime respectively, and both gave linear response to concentration of at least 80 mcg/ml. Drug recovery after sample deproteination was 104% for BMY-28142 in rabbit serum and 93% in human serum. Results indicate a precise and accurate assay for this drug can be obtained using a simple LC method.Keywords
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