Renal Function in Fischer 344 Rats with Chronic Renal Impairment after Administration of Enflurane and Gentamicin

Open Access
Publisher Website
Google Scholar
Abstract
To assess the potential for producing nephrotoxicity in rats with abnormal renal function, the renal effects of enflurane or halothane anesthesia, 1 MAC [minimum anesthetic concentration] for 2 h, were examined in 6 groups of 6 Fischer 344 rats each with surgically induced chronic renal impairment. As an additional predisposing factor, gentamicin, 5 mg/kg per day, was administered for 1 wk before and for 1 wk after anesthesia to 3 of the groups, one anesthetized with enflurane, one anesthetized with halothane and one unanesthetized. No significant change in renal function could be attributed to either anesthetic agent. Serum inorganic fluoride levels 4 h and 24 h after enflurane anesthesia were similar in the gentamicin-treated and the non-gentamicin-treated groups. Clinically small but statistically significant increases in serum creatinine concentration and urinary flow occurred in all 3 gentamicin-treated groups during the period of treatment. Anesthesia with enflurane or halothane in rats with chronic renal impairment treated with gentamicin did not result in additional renal damage.