THE INHIBITION OF TWO STEROID-ACTIVATED NICOTINAMIDE-ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASES BY FOLIC ACID AND FOLIC ACID ANTIMETABOLITES
- 1 March 1965
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 94 (3) , 773-777
- https://doi.org/10.1042/bj0940773
Abstract
It was found that steroid-mediated nicotinamide -adenine dinucleotide (phosphate) transhydrogenases can be inhibited in vitro by folic acid and its antimetabolites. The most potent inhibitor was Methotrexate, a drug with a high therapeutic index against experimental cancer. The inhibitions produced by a combination of folic acid and the analogues were additive, as were those between the folic acid compounds and antagonistic steroid hormones.Keywords
This publication has 16 references indexed in Scilit:
- The inhibition of 3α-hydroxy steroid-activated nicotinamide-adenine dinucleotide (phosphate) transhydrogenase by some antimetabolic compoundsBiochemical Journal, 1964
- ON THE MECHANISM OF ACTION OF ALDOSTERONE ON SODIUM TRANSPORT: THE ROLE OF PROTEIN SYNTHESISProceedings of the National Academy of Sciences, 1963
- Early estrogen effects on newly synthesized RNA and phospholipid in subcellular fractions of rat uteriArchives of Biochemistry and Biophysics, 1963
- Purification and properties of the 3α-hydroxy steroid-dependent nicotinamide-adenine dinucleotide transhydrogenase of rat liverBiochemical Journal, 1963
- CONTROL OF GLUCOSE OXIDATION IN ANTERIOR PITUITARY BY HORMONALLY SENSITIVE PYRIDINE NUCLEOTIDE TRANSHYDROGENASEProceedings of the National Academy of Sciences, 1962
- AN EFFECT OF TESTOSTERONE ON AMINO ACID INCORPORATION BY PROSTATIC RIBONUCLEOPROTEIN PARTICLESProceedings of the National Academy of Sciences, 1962
- Incorporation of ribonucleoside triphosphates into ribonucleic acid by nuclei of the prostate glandBiochimica et Biophysica Acta, 1962
- Relationship of 3α-Hydroxysteroid Dehydrogenase to Pyridine Nucleotide TranshydrogenasesScience, 1959
- Estradiol-sensitive isocitric dehydrogenase in noncancerous and cancerous human breast tissueCancer, 1958
- Studies on the mechanism of action of estrogens.1958