SALICYLATE ENHANCEMENT OF RENAL GLUCURONIDE CONJUGATION AND TUBULAR EXCRETORY TRANSFER OF PHENOLS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 10  (6) , 573-578
Abstract
Salicylate administration increased glucuronyltransferase activity, with o-aminophenol as the substrate, in chicken kidney homogenates but did not affect glucuronyltransferase activity in chicken liver homogenates. Salicylate administration increased in vivo renal glucuronidation of catechol and p-nitrophenol without affecting renal sulfate conjugation of these compounds. Salicylate administration selectively enhances renal glucuronide conjugation, thereby promoting a more rapid metabolism and elimination of circulating phenols, especially at high plasma phenol concentrations. Isolated human kidney perfusion experiments reveal that glucuronide and sulfate conjugates of phenol, p-nitrophenol and 1-naphthol are formed in the human kidney, suggesting that the effect of salicylate treatment on renal glucuronidation may apply to humans.