Trimethoprim, Metioprim, Tetroxoprim, and RO 10‐5970 in Canine Bone
- 1 November 1982
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 51 (5) , 446-449
- https://doi.org/10.1111/j.1600-0773.1982.tb01051.x
Abstract
The penetration of trimethoprim and 3 derivatives into bone tissue was investigated in a dog model. The trimethoprim derivative RO 10-5970 [brodinoprim] concentrates well in bone tissue with median tissue-to-serum concentration ratios of 0.23 in cortical bone and 0.81 in both medulla and cancellous bone. The use of RO 10-5970 in osseous infections is appealing because oral administration is possible.Keywords
This publication has 6 references indexed in Scilit:
- Osteomyelitis: The Past DecadeNew England Journal of Medicine, 1980
- Treatment of experimental staphylococcal osteomyelitis with rifampin and trimethoprim, alone and in combinationAntimicrobial Agents and Chemotherapy, 1980
- Activity of tetroxoprim and sulphadiazine alone and in combination on Gram-negative bacteriaJournal of Antimicrobial Chemotherapy, 1979
- Pharmacokinetics of tetroxoprim and sulphadiazine in various speciesJournal of Antimicrobial Chemotherapy, 1979
- A New Method for Homogenization of Bone Exemplified by Measurement of Trimethoprim in Human Bone TissueActa Pharmacologica et Toxicologica, 1975
- Trimethoprim-sulphamethoxazole in Acute Osteomyelitis Due to Penicillin-resistant Staphylococci in UgandaBMJ, 1970