Pure Synthetic Bile Salts Release Immunoreactive Secretin in Man

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Abstract
When 20 ml of 50 mmol/l pure synthetic bile salts (pH 6.5), of approximately the same composition as human bile, were infused into the duodenum of 6 healthy volunteers over 5 min during constant gastric aspiration, plasma immunoreactive secretin increased from 2.5 .+-. 0.4 pmol/l to 3.6 .+-. 0.5 pmol/l at 10 min (P < 0.025). Gastric acid secretion was not increased. No effect was seen when the same amount of physiological saline was infused under the same conditions in another group. Bile salts in an amount and composition corresponding to that in the human gallbladder is apparently able to release immunoreactive secretin from the human intestine.