Synthesis of two 6′α-fluorocarbocyclic nucleosides and incorporation into short segments of DNA
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 20,p. 2633-2641
- https://doi.org/10.1039/p19920002633
Abstract
The 6′-fluorocarbocyclic nucleosides 1 and 2 have been synthesized from the bicyclic ketone 3 in 16 and 2% yield respectively. The nucleoside 1 has been incorporated into short chains of DNA using an automated synthesizer and these oligonucleotides have been shown to hybridize with (fluorine containing) complementary strands.Keywords
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