Blood Levels of Penicillin After Oral Administration With Various Antacids

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Abstract
Subjects on a soft diet, low in protein and fat, were given 100,000 units of Ca penicillin plus the equiv. of 2.5 g. of an antacid. Aluminum hydroxide, Mg trisilicate and Mg(0H)2 were given as magmas or gels. Trisodium citrate and aluminum dihydroxy amino acetate were used as tablets containing penicillin. In control tests, penicillin was given in tap water. Blood samples were taken each hr. for 4 hrs., and urine up to 6-12 hrs. Blood levels of penicillin were detd. by the Fleming slide cell method and urine concs. by the Oxford cup method. Penicillin was present in blood up to 11/2-2 hrs. when given on an empty stomach and its excretion varied from 6.6-15.9%. It was present at the most up to 1 hr. when given on a full stomach and its excretion was 0.48-1.9%. 100,000 units given orally in tap water to a pernicious anemia patient caused a blood level of 0.24 units/ml. up to 3 hrs. and a level of 0.03 at 4 hrs. Urinary excretion was 24.2%. All antacids gave striking increases in penicillin blood levels as compared to tap water controls. There were no prolonged blood levels when penicillin was given in single or divided doses with aluminum hydroxide gel.