THE EFFECT OF VITAMIN B12 AND BIOTIN ON THE METABOLISM OF VITAMIN B12 IN BIOTIN-DEFICIENT RATS

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Abstract
The effect of the administration of vitamin B12 and biotin on the metabolic pattern of vitamin B12 in biotin-deficient rats was studied. No significant changes in the absorption and excretion of orally administered [Co58]vitamin B12 were noted either in vitamin B12-treated and or in biotin-fed rats. A significant decrease of the uptake of orally given [Co58] vitamin B12 was observed in the liver and kidneys of biotin-treated rats, whereas an increase of uptake in the kidneys of vitamin B12 -treated rats was noted as compared with biotin-deficient animals. No significant difference in the excretion of radioactivity was noted between biotin deficient and biotin-fed rats when [Co58] vitamin B12 was administered by injection. A small decrease was observed in vitamin B12 -treated rats. The retention of injected [Co58]vitamin B12 by major organs of biotin-treated rats was lower than that of biotin-deficient rats. A lower content of [Co58]vitamin B12 was also detected in the organs, with the exception of the kidneys, of vitamin B12-treated rats. These results are discussed in terms of an interrelationship between biotin and vitamin B12.