Effect of convulsions on cerebrospinal fluid and plasma activity of glutamic oxalacetic transaminase and lactic dehydrogenase

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Abstract
The effect of prolonged convulsions induced by Metrazol or electroshock on plasma and cerebrospinal fluid glutamic oxalacetic (GOT) and lactic dehydrogenase (LDH) activity was studied in 40 puppies. Seizures of longer than 30 minutes'' duration produced plasma and cerebrospinal fluid activity of GOT and LDH that was approximately 3 times greater than in controls. The mean increase in plasma enzyme activity was similar to that in the cerebrospinal fluid. Cisternal fluid/plasma radioactivity concentration ratios of albumin-I131 were measured concomitantly with the enzyme determinations and demonstrated increased permeability of the blood-cerebrospinal fluid barrier to albumin. Cisternal fluid/plasma GOT and LDH ratios were essentially similar in the control and experimental groups, suggesting no major increase in permeability of the blood-cerebrospinal fluid barrier to these enzymes. Elevated cerebrospinal fluid GOT and LDH activity immediately following prolonged seizures probably reflects an increase in cerebral cell membrane permeability rather than actual cellular lysis, and increased permeability of the blood-cerebrospinal fluid barrier to the enzymes is apparently not a major factor.

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