The onset of lactose synthesis after injection of prolactin

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Abstract
The initial stages of lactose synthesis in the intact rabbit at the sites of mammary-intraductal injections of prolactin (lactogenic hormone) were studied by a modified chromato-graphic method that allows the determination of lactose in mammary glands down to a concentration of 10 [mu]g/100 mg of tissue. The following features of the lactogenic response are described the total absence of lactose from non-lactating mammary glands; the sharp rise in lactose synthesis occurring in the mammary glands on the fifth day after local treatment with prolactin; the relationship of the true amounts of lactose and glucose present to the reducing value of a crude mammary-gland homogenate.