STUDY OF THE HYPERGLYCEMIC ACTIVITY OF NORMAL HUMAN URINE1

Publisher Website
Google Scholar
Abstract
The intravenous administration of pancreatin or an a-amylase of bacterial origin did not affect the blood sugar of the rabbit. Pancreatin and a-amylase induced an increase in the amount of reducing matter released into the medium by rabbit liver slices incubated in vitro. A urinary extract previously found to be hyperglycemic and glycogenolytic appears to stimulate in vitro glycogenolysis, not through an intracellular mechanism but by the action of urinary amylase on glycogen that has escaped from the cells into the medium. The urinary extract was shown to decrease the blood pressure of the rabbit. Hyperglycemia following the administration of the urinary extract can be completely inhibited by the adrenolytic drug Hydergin. Extracts of normal human urine prepared by the method of Meduna were shown to be hyperglycemic when the material was given intravenously. These extracts also are hypotensive and their hyperglycemic action is inhibited by Hydergin.