HYPERGLYCEMIC AND GLYCOGENOLYTIC ACTIVITY OF PREPARATIONS FROM HUMAN URINE1

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Abstract
A crude concentrate or an alcohol-insoluble fraction derived from the urine of normal men and women has consistently been found to be hyperglycemic and to induce an increased release of glucose by rabbit liver slices in vitro. Unlike pancreatic glucagon, the urinary factor is very active in stimulating glycogen breakdown in liver homogenates. It is concluded that the glycogenolytic activity of urinary preparations is at least partially due to a factor other than pancreatic glucagon. Uric acid, growth hormone, Pitressin, adenosine-5-phosphoric acid and Ca ion failed to stimulate glycogenolysis in rabbit liver homogenates.