THE EFFECTS OF EPINEPHRINE ON URINE EXCRETION IN DOGS

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Abstract
Rapid rates of epinephrine infusion in anesthetized dogs with trachea, carotid artery, and ureters cannulated, resulted in oliguria; slow rates resulted in polyuria. Intramuscular and subcut. injs. into anesthetized, or unanes-thetized dogs, with urinary bladder fistulas, always resulted in polyuria. Injecting the epinephrine in 2 places, or massaging the injected area, did not have a permanent effect on the polyuria in the fistula dogs. The urinary urea concn. decreased after epinephrine administration. The urea and chloride excretion rates varied directly as the water excretion rates. Rapid rates of epinephrine infusion which resulted in oliguria usually produced pro-teinuria; rates which resulted in polyuria, or injs. which brought about this response, had no effect on the protein excretion.