The hydrolysis of triphosphoinositide by extracts of ox brain

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Abstract
Sodium triphosphoinositide was rapidly hydrolysed when incubated with dialysed extracts of acetone-dried ox brain. The hydrolysis products were identified as inorganic phosphate, inositol diphos-phate, inositol triphosphate, diglyceride and monophosphoinositide. The addition of diethylether to the incubation medium greatly increased the amount of diglyceride and inositol phosphoesters formed and decreased inorganic phosphate and monophosphoinositide. Diphosphoinositide accumulated as a transient intermediate during the hydrolysis. The results were interpreted to mean that triphosphoinositide was broken drown by the following main pathways: [image].