Bone and Mineral Metabolism in Hyperthyroidism: An Experimental Study

Publisher Website
Google Scholar
Abstract
The effect of thyroxine-induced hyperthyroidism on bone and on mineral metabolism was studied in adult, parathyroid intact and parathyroidectomlzed dogs. Contrary to the findings in earlier studies, experimentally induced hyperthyroid-ism was found to cause an increase in bone turnover, an increase in the serum Ca and a decrease in the plasma protein concentrations in both groups of animals. In the parathyroid intact dogs an additional feature was the development of hyperphosphatemia. These results establish that the increased bone resorption found in hyperthyroidism is independent of the parathyroid glands. The tendency to hypercalcemia may be the result of the increased bone resorption. The change in the serum POE concentration may be the result of suppressed parathyroid activity consequent upon the increased mobilization of Ca.