Urinary Excretion of Parathyroid Hormone in Man: Effects of Calcium Loads, Protein-Free Diets, Adrenal Cortical Steroids and Neoplastic Disease1

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Abstract
Parathy-roid hormone excretion has been measured in human urine by bioassay in parathyroidectomized rats. Measurements were made in normals, in hyperparathyroidism and in hypoparathyroidism. Hormone excretion fell to zero with calcium loading and in a patient with vitamin D intoxication. Protein-free diets also resulted in disappearance of the hormone from the urine and in decreased intestinal calcium absorption. A patient with hypoparathyroidism, maintained with parathyroid extract, failed to show significant changes in urinary of fecal calcium on the protein-free regimen. Cortisol or prednisone in sufficiently high doses resulted in disappearance of the urinary hormone. Of 8 patients with neoplastic disease, osteolytic lesions, hypercalcemia and hypercalciuria, 2 had significantly elevated hormone excretions and one was slightly elevated. Three patients with neoplastic disease, osteolytic lesions and normal serum and urinary calcium values exhibited normal hormone excretions.