Effect of hyperthermia on human melanoma cells heated either as solid tumors in athymic nude mice orin vitro
- 1 October 1982
- Vol. 50 (7) , 1304-1308
- https://doi.org/10.1002/1097-0142(19821001)50:7<1304::aid-cncr2820500715>3.0.co;2-h
Abstract
Human melanoma cells were exposed to clinically acceptable hyperthermia (42.5°C) either as solid tumors in athymic nude mice or suspended in culture medium. Single cell survival was in both cases assayed in vitro in soft agar. The response to heat varied considerably among the five melanomas studied. The D0-values ranged from 21 to 590 min when the cells were heated in vitro. The response to heat following treatment in vivo was for a given melanoma larger than that following treatment in vitro. However, cells which were resistant to heat treatment in vitro, were also resistant to treatment in vivo, and those which were sensitive in vitro were also sensitive in vivo.This publication has 18 references indexed in Scilit:
- Radiation response of two human malignant melanomas grown in athymic nude micePublished by Elsevier ,1981
- Microwave-induced local hyperthermia in combination with radiotherapy of human malignant tumorsCancer, 1980
- Hyperthermia in the treatment of cancerCancer Treatment Reviews, 1979
- Combination hyperthermia and radiation therapy for cutaneous malignant melanomaCancer, 1978
- Local tumor hyperthermia in combination with radiation therapy.1. Malignant cutaneous lesionsCancer, 1977
- Response of Extremely Hypoxic Cells to Hyperthermia: Survival and Oxygen Enhancement RatiosRadiology, 1977
- Cellular Responses to Combinations of Hyperthermia and RadiationRadiology, 1977
- Hyperthermic potentiation.Biological aspects and applications to radiation therapyCancer, 1977
- Enhanced killing of hypoxic tumour cells by hyperthermiaThe British Journal of Radiology, 1975
- Killing of Chinese hamster cells in vitro by heating under hypoxic or aerobic conditionsPublished by Elsevier ,1974