Antithyroid drugs and radioactive iodine. Fifteen years' experience with Graves' disease
- 1 June 1979
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 139 (6) , 651-653
- https://doi.org/10.1001/archinte.139.6.651
Abstract
The population for this study included 186 patients who were treated between 1962 and 1977 for diffuse toxic goiter. Patients were divided into 2 groups according to the primary mode of therapy, which was thioamides or 131I-NaI. Of 96 patients who were treated with primary drug therapy, only 16% experienced a prolonged remission (more than 2 yr) of hyperthyroidism. Except for a greater likelihood of remission among patients with mild hyperthyroidism, no other clinical features of Graves'' disease were predictive of the long-term response to drug therapy. Among the 90 patients who received primary 131I-NaI therapy, those who were pretreated with thioamides required a higher total dose to achieve a cure (13.8 vs. 9.6 mCi) and had a lower initial incidence of hypothyroidism (54 vs. 73%).This publication has 7 references indexed in Scilit:
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