Intravascular Effect of Heparin on Plasma Nonesterified Fatty Acid and Triglyceride During Alimentary Lipemia

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Abstract
The lipolytic activity of human post-heparin plasma was completely inhibited by p-nitro-diethyl-phenyl-phosphate (2 X 10"3 molar), but incompletely inhibited by cooling to 4[degree]C. When in vitro lipolysis was prevented, the injection of heparin (10 mg intravenously) did not significantly influence the clearance of triglyceride from plasma during alimentary lipemia. Injection of heparin in lipemic subjects caused a small rise in the nonesterified fatty acid concentration of the plasma, but the quantity of triglyceride hydrolysed was insignificant in relation to its large turnover rate.