Extramedullary Disease in Acute Promyelocytic Leukemia
- 1 January 1999
- journal article
- case report
- Published by Taylor & Francis in Leukemia & Lymphoma
- Vol. 33 (3-4) , 219-229
- https://doi.org/10.3109/10428199909058422
Abstract
All-transretinoic acid (ATRA) is currently recommended as standard treatment for acute promyelocytic leukemia (APL). However there has been increasing concern that ATRA is associated with unusual sites of relapse. Although there is insufficient evidence so far to substantiate this, we review the potential mechanisms by which ATRA may increase the incidence of extramedullary and, in particular, central nervous system (CNS) relapse.Keywords
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