Rapid and reversible disappearance of beta-adrenergic cell surface receptors.
Open Access
- 1 February 1982
- journal article
- research article
- Published by Wiley in The EMBO Journal
- Vol. 1 (2) , 187-190
- https://doi.org/10.1002/j.1460-2075.1982.tb01145.x
Abstract
The water soluble beta‐adrenergic ligand [3H]CGP‐12177 was used to measure the cell surface receptors in intact cells. In two cell lines, C6 glioma and WEHI 7 lymphoma cells, ‐50% of the cell surface receptors disappear within minutes of incubation of the cells with isoproterenol. The receptors can still be detected in homogenates and reappear on the cell surface when cells are washed and reincubated at 37 degrees C. The data agree with a disappearance of the receptors from the cell surface by an agonist‐mediated endocytosis.This publication has 17 references indexed in Scilit:
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