Antiarrhythmic effects of a novel diamine derivative, AN-132, on several animal models of cardiac arrhythmias.

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Abstract
The antiarrhythmic activities of AN-132, 3-(diisopropylaminoethylamino)-2'',6''-dimethylpropionanilide .cntdot. 2H3PO4, compared with three reference drugs, were examined in several arrhythmic models of rats, guinea-pigs and dogs. When compared on a weight basis, AN-132 given in oral or i.v. route proved to be more potent and longer-acting than disopyramide, propaphenone and mexiletine against supraventricular and ventricular arrhythmias induced by chloroform, aconitine, ouabain, and halothane-adrenaline.